地震中控制血糖真难
在成都住在外面,精神还是紧张,女儿持续高.天天都觉的地在晃. 一有余震就得冲到外面.
刚震时还得冒着危险转回到6楼取药,血糖表.
这次地震真的很感慨,说的是打了针就和常人一样, 可还是不一样啊!想一想没有胰素72小时?
看来一型得在家随手准备个应急包.
看到一篇文章,说是发现肠内的神经是控制大脑指挥肝放糖的摇控器. 10年有望有药.
Discovery key to diabetes breakthrough?
Toronto researchers find a set of nerves in the intestines which are key to elevating blood glucose
April 9, 2008
Joseph Hall
HEALTH REPORTER
In a major new discovery, Toronto scientists have shown that the intestines play a critical role in causing high blood sugar levels, research that they say could make it far easier to produce safer and more effective diabetes medications.
The University Health Network study shows that a set of nerves in the intestines - one of the easiest organs in the body to hit with medication - is intimately involved in elevating blood glucose to levels that can cause the myriad ailments of diabetes.
The research was published today in the prestigious journal Nature.
It shows for the first time that the intestines are part of a three-organ signalling system that ultimately controls the amount of glucose the liver sends into the bloodstream.
"The cure for diabetes is to lower blood glucose levels ..... and this will be an innovative and effective approach to do that," says physiologist Tony Lam, the senior study author.
Lam published heralded work last year that showed how overeating could shut down the brain's ability to stop the liver from churning out too much triglyceride fat, another key product of the organ.
This latest paper shows that overeating fatty foods can also disrupt the liver's neurological glucose control switch as well.
In the new paper, however, Lam's Toronto General Hospital Research Institute team went back another step, to show how a cluster of nerves in the intestines actually control the brain's ability to turn off the liver's glucose production.
"Last year we only talked about the brain and the liver," says Lam, who is also a University of Toronto physiologist.
"But this year it's a completely new circuit, which begins with the intestines serving like a remote-control device that signals the brain to regulate glucose production."
Normally, the liver produces glucose between meals - or fasting times - to provide the body's cells with the sugary fuels they need to work and survive.
At meal times, however, the brain signals the liver to shut down its glucose production, with the body able to access the ready nutrients provided by the incoming food.
But Lam says it is the intestinal nerves - discovered by his team in rats - that sense the presence of food and signal the brain to shut down the liver's glucose machinery.
Critically, however, Lam's team also found that a high fat diet could turn off this three-organ signalling system. Indeed, after only three days of fatty foods, the circuitry was completely disrupted, forcing the rat livers into continuous glucose production.
Diabetes is fundamentally a problem of the pancreas, which produces too little glucose metabolizing insulin in the ailment.
But Lam says the damage the disease can cause - including blindness, amputations and cardiovascular problems - is actually caused by an excess of sugars in the blood. Lowering blood glucose to more normal levels would provide an effective treatment for the chronic condition, he says.
The discovery of the gut's role in glucose regulation could make it far easier to design drugs to correct blood sugar problems, Lam says.
He says it's far easier to design drugs to "hit" the gut, than either the liver or the brain, with the latter being especially difficult to target because of a natural barrier that protects it from unwanted blood-borne substances.
As well, he says, drugs that need to enter the blood stream to hit target organs like the brain and liver are quickly broken down once they enter that circulatory system.
The gut, however, need not rely on blood for drug delivery, being able to access medications directly from the mouth.
"If the brain is such an important organ to lower ..... glucose levels, but is so difficult to hit, why don't I hit something that is more available and more feasible," Lam says. "The drug will never have to hit the brain, but I can still tell the brain with a remote button (in the gut) to lower glucose levels."
Lam says he does not know if the same gut-brain-liver circuitry is involved in other liver functions, like fat production. But there is a good possibility it is, he says.
Dr. Gary Lewis, head of endocrinology and metabolism at UHN and Mount Sinai Hospitals, says Lam's work is "a major discovery of a new pathway," in blood sugar control.
But Lewis, a U of T medical professor, says research that would render a medication from the discovery is likely more than 10 years off.
Lewis calls the intestinal nerves an "early warning system" to switch off the liver's glucose production.
thestar.com
http://bbs.tnbz.com 2008-5-18 11:01 PM
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