最近《科学》杂志报告:胰岛素水平与小鼠寿命有关联
New research claims that reducing insulin signals inside brain cells increases lifespan in mice.
最新研究表明:降低大脑内部的胰岛素信号延长了小鼠的寿命。
Researchers also concluded that having a healthy lifestyle and weight that reduces insulin levels could also be an important factor in increasing longevity in humans.
研究人员还得出结论:拥有健康的生活方式及其对于胰岛素水平需求较低的体重是一个延长人类寿命的重要因素。
The study, conducted by researchers from the the Howard Hughes Medical Institute in the US is published today in Science journal. The research looked at the effects of a protein, IRS2, which carries the insulin signal in the brain and showed that the mice with half the amount of the protein lived 18 per cent longer than normal mice.
该项研究是由美国霍华德.休斯研究所做出的,结果发表在最近的《Science》杂志上面。研究人员还检查了IRS2(Insulin Receptor Substrates)蛋白的效应,该蛋白能够传递胰岛素信号。当小鼠中该蛋白的含量只有一半时,它的寿命增加了18%。
"This is an interesting study as the work done on mice could suggest that insulin is playing a role in the ageing process,” said Matt Hunt, Science Information Manager at Diabetes UK.
这项在小鼠中做的研究挺有意思,它暗示着胰岛素在衰老的进程中扮演着某种角色。
"Nevertheless, we are looking at numerous and extremely complex gene interactions in the brain and this research doesn't yet explain how this mechanism might be working.
然而,我们正在研究大脑中的其他几个而且非常复杂的基因互作关系,这项研究还未解释这种机制是怎样运行的。
“We have to remember that human longevity has been steadily increasing, despite rising levels of obesity and diabetes, due to improvements in access to healthcare, clean water and better public health initiatives. This means that insulin levels in the brain would be only one of many factors when it comes to improving longevity.
我们必须明白,尽管肥胖与糖尿病的发病率逐年上升,但是人类的寿命却一直稳步增长,这主要是由于人们获得更好的医疗服务、洁净的水源与更好的公共卫生活动。这也意味着大脑中胰岛素的水平,可能仅仅是影响寿命的众多因素中的一个。
"We welcome the fact that this study supports Diabetes UK's key message of the importance of leading a healthy lifestyle, including having a balanced diet and taking enough physical activity, to improve health outcomes.
我们欢迎这样的事实,即该项研究支持了英国糖尿病组织宣称的主要信息-实行健康生活方式的重要性,其中包括坚持足够的身体活动来提高身体健康。
"Although quite speculative it would be interesting to see how the authors think their findings might be applied to humans."
作者是如何将该项发现用于人类,这一定是非常有趣的事情,尽管只是处于猜测的阶段。
http://bbs.tnbz.com 2007-7-30 03:36 PM
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