2型糖尿病卒中发病风险翻倍

Title:Short-Term Risk for Stroke Is Doubled in Persons With Newly TreatedType 2 Diabetes Compared With Persons Without Diabetes
题目：2型糖尿病卒中发病风险翻倍
Author:Thomas Jeerakathil, MD, MSc; Jeffrey A. Johnson, PhD; Scot H. Simpson, PharmD, MSc Sumit R. Majumdar, MD, MPH
作者：Thomas Jeerakathil, MD, MSc; Jeffrey A. Johnson, PhD; Scot H. Simpson, PharmD, MSc Sumit R. Majumdar, MD, MPH
Resource:Stroke. 2007;38:1739.
来源：《卒中》，2007；38：1739
ABSTRACT
摘要
Backgroundand Purpose— Cardiovascular risk factors are suboptimally treated indiabetes, possibly because of the impression that there is a long delaybetween diagnosis and the development of macrovascular complicationssuch as stroke. We determined the incidence of stroke in people newlytreated for type 2 diabetes.
背景与目的：糖尿病的心血管并发症一直不能得到有效的治疗，可能是因为血管病变从产生到诊断有一个时滞比如卒中。目的研究2型糖尿病患者卒中发生率。
Methods—We conducted an inception cohort study with the use of linkedadministrative databases from Saskatchewan Health. Subjects entered thetype 2 diabetes cohort on receipt of their first prescription for anoral antidiabetic drug. We defined incident stroke as any hospitaladmission with International Classification of Diseases, NinthRevision, codes 430 to 438 inclusive. Age-standardized incidence rateswere compared between the diabetes cohort and the general population.
方法：使用Saskatchewan健康中心提供管理数据库进行回顾性队列研究。目标为首次服用口服降糖药后的2型糖尿病患者。卒中发生照医院普遍承认的国际糖尿病分类第9次修订本，430－438页标准。年龄标准化卒中发生率采取糖尿病队列人群与正常人群相对照。
Results—There were 12 272 subjects in the diabetes cohort, the mean±SD age was64±13.6 years, and 55% were male. During a mean 5-year follow-up, 9.1%of the diabetes cohort had a stroke. The age-standardized incidencerate for stroke was 642 per 100 000 person-years in subjects withdiabetes, compared with 313 per 100 000 person-years in the generalpopulation (rate ratio=2.1, 95% CI=1.8 to 2.3). The relative short-termrisk for stroke in the diabetes cohort compared with the generalpopulation ranged from 1.8 (95%=CI 1.6 to 1.9) in persons >75 yearsto 5.6 (95% CI=2.5 to 9.3) in the 30- to 44-year category.
结果：糖尿病队列12272个糖尿病患者中，平均年龄为64±13.6岁，其中55%为男性。平均随访时间为5年，有9.1%的患者发生卒中。此年龄段的糖尿病患者卒中发生率为642/10万人•年，正常人313/10万人•年（率比=2.1，95%，置信区间=1.8-2.3）。分析75岁以上与30-44岁糖尿病患者糖尿病队列短期卒中发生率，卒中发生率比范围在1.8(95%CI =1.6 to 1.9)到5.6 (95% CI=2.5 to 9.3)之间。
Conclusions— The riskof stroke is high within 5 years of treatment for type 2 diabetes andmore than double the rate for the general population. This furthersupports the need for aggressive early cardiovascular risk factormanagement in type 2 diabetes.
结论：糖尿病诊断5年内卒中发病危险翻2倍。进一步论证了糖尿病防治早期心血管并发症的必要性。



编译后:

题目：2型糖尿病卒中发病风险翻倍
作者：Thomas Jeerakathil, MD, MSc; Jeffrey A. Johnson, PhD; Scot H. Simpson, PharmD, MSc Sumit R. Majumdar, MD, MPH
来源：《卒中》，2007；38：1739
摘要
背景与目的：糖尿病的心血管并发症一直不能得到有效的治疗，可能是因为血管病变从产生到诊断有一个时滞比如卒中。目的研究2型糖尿病患者卒中发生率。
方法：使用Saskatchewan健康中心提供管理数据库进行回顾性队列研究。目标为首次服用口服降糖药后的2型糖尿病患者。卒中发生照医院普遍承认的国际糖尿病分类第9次修订本，430－438页标准。年龄标准化卒中发生率采取糖尿病队列人群与正常人群相对照。
结果：糖尿病队列12272个糖尿病患者中，平均年龄为64±13.6岁，其中55%为男性。平均随访时间为5年，有9.1%的患者发生卒中。此年龄段的糖尿病患者卒中发生率为642/10万人•年，正常人313/10万人•年（率比=2.1，95%，置信区间=1.8-2.3）。分析75岁以上与30-44岁糖尿病患者糖尿病队列短期卒中发生率，卒中发生率比范围在1.8(95%CI =1.6 to 1.9)到5.6 (95% CI=2.5 to 9.3)之间。
结论：糖尿病诊断5年内卒中发病危险翻2倍。进一步论证了糖尿病防治早期心血管并发症的必要性。